Pharmacogenomics objectives and Resources
This section discusses the attempt to optimize drug therapies based on the patient’s DNA. Examples such as HER2/neu and Warfarin are discussed. (22 slides)
- Explain how pharmaceutical companies may develop drugs using molecular techniques to tailor the drug to each patient.
- Describe why a patient’s Her-2 status changes their response to Herceptin.
- Explain how 2 different patients may have varying responses to the same drug based on their DNA.
- Describe how Warfarin (Coumadin) is tolerated differently depending on the patient’s genetics.
http://learn.genetics.utah.edu/content/health/pharma/ Genetics and Health, Personalized Medicine: a. Your Doctor’s New Genetic Tools, b. Making SNPs Make Sense, c. Drug Development Today and Tomorrow. 3 modules, which talk about genetics and drug development. The interactive frog module is kind of fun also but may be too “young” for our students
Resource: Roche CD, Genetics, Pharmacogenetics – The Gene Scene; Ethical, Legal, and Social Issues – Genetics and Medicine
Readings: Roche CDs on Genetics – Pharmacogenetics; Genetics and Medicine “Learn genetics” site above