Chapter 7.1

Circulating Tumor Cells Objectives and Resources

The search for the presence of metastatic disease is an important one for clinicians and patients. This system uses biomarkers and computers to present cells of interest to the technologist for evaluation as potential metastatic tumor cells. This approach may be very beneficial to direct future therapy for the patient. This section discusses the process of metastasis, the detection of circulation tumor cells in blood, various methods of detection, the CellSearch® technique, advantages and disadvantages, and method of operation.


  • Outline basic steps in the process of cancer cell metastasizing via the bloodstream
  • Discuss the clinical utility of identifying circulating tumor cells in the blood
  • Explain basic concepts in the CellSearch® System.