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Archive Item Code: 3600-B
Item Name: Next Generation Sequencing and Cytopathology: The Future is Now
Cory Bernardt, MD, PhD
Presentation Date: May 27, 2014; Expires: May 27, 2017
Molecular testing of cancer is increasingly critical to medicine. The development of targeted therapeutics has brought the concept of personalized medicine to the forefront. Next-generation sequencing (NGS) is proving to be a powerful tool for identifying diverse genetic mutations across numerous genes. Cytology specimens, particularly fine needle aspirations, are typically the first, and often the only, specimen available for diagnosis and ancillary testing. This webinar will introduce NGS, and describe how cytology specimens can be utilized for NGS to improve patient care.
Archive Item Code: 3600-E
Item Name: Pap Test and HPV Correlation: The Value of Morphology
Barbara McGahey Frain, MS, CT(ASCP)
Presentation date: August 26, 2014; Expires: August 26, 2017
The focus of this archive will be a case-based approach to Pap Tests with expected, as well as unexpected high risk HPV results. Clinical/histologic follow up will be provided. Some unusual conditions will be addressed. Technical considerations and trouble-shooting based on one organization’s experience will be included.
Archive Item Code: 3500-J
Item Name: Exfoliative Cytology of the Extrahepatic Biliary Tract: Morphologic Assessment and Ancillary Testing
Lester J. Layfield, MD
Presentation Date: January 28, 2014; Expires: January 28, 2017
The morphologic features of extrahepatic biliary tract malignancies can be subtle and the implications of such a diagnosis are significant. This webinar reviews the diagnostic criteria for the diagnosis of adenocarcinoma in exfoliative samples and provides information on ancillary molecular testing.
Archive Item Code: 3500-F
Item Name: Diagnostic Approach to Lymphoproliferative Neoplasms in Cytology Specimens
Oscar Lin, MD, PhD
Presentation Date: September 24, 2013; Expires: September 24, 2016
Lymphoproliferative lesions are commonly seen in cytology specimens, including needle aspirations as well as exfoliative cytology. Accurate diagnosis of these lesions requires correlation of the morphologic findings with ancillary studies and clinical findings. Knowledge of the limitations in cytology cases is important to avoid unnecessary work up and misinterpretation. The objective of this presentation is to provide a methodological approach to lymphoproliferative lesions in cytology specimens.
Item Code: 3500-C
Item Name: Integration of Molecular Ancillary Techniques into Routine Cytology Practice: Issues in Current State of the Art and Critical Future Trends
Stewart M. Knoepp, MD, PhD
Presentation Date: June 25, 2013; Expires: June 25, 2016
First, a brief overview of important molecular tests for cytologic specimens will be discussed. Information provided will be based on ordering, practice patterns, and experience at a large academic medical center, a multi-state private co-tenancy laboratory, and extensive literature review.
Next, an optimized approach for triaging cytologic tissue for accurate cytologic diagnosis as well as the performance of clinically relevant ancillary studies will be presented. Selected clinical scenarios and molecular tests will be discussed.
Lastly, the future need for optimization of molecular testing on cytology specimens in a coordinated-care environment (e.g. accountable care organizations) will be discussed.
Item Code: 3400-B
Item Name: Who’s Afraid of Urine Cytology? From Morphology to Molecular Testing
Güliz A. Barkan, MD, FIAC
Presentation Date: May 22, 2012; Expires: May 22, 2015
Urine cytology is often thought to be one of the most challenging specimens. In this conference the morphological criteria, approach to diagnosis, differential diagnosis, and potential pitfalls will be discussed. Common ancillary tests utilized (especially FISH), the usage in practice and limitations will be presented.
Item Code: 3400-I
Item Name: Molecular Diagnostics in Thyroid FNA Samples
Marina N. Nikiforova, MD
Presentation date: December 11, 2012; Expires: December 11, 2015
Fine needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate clinical management. Somatic mutations and other molecular alterations have been recognized as helpful diagnostic and prognostic markers for thyroid cancer. Molecular testing for BRAF, RAS, RET/PTC, and PAX8/PPARγ mutations is feasible in clinical FNA samples, helps to improve the diagnostic accuracy of FNA cytology, and offers a valuable tool for management of patients with thyroid nodules.
Item Code: 3400-J
Item Name: Molecular Aspects of Cervical Cancer Screening
G. Denice Smith, PhD, CT (ASCP)
Presentation date: January 22, 2013; Expires: January 22, 2016
The role for molecular testing in cervical cancer screening continues to be discussed and debated in cytology. This webinar will summarize current molecular test options for cervical cancer screening, including tests for the presence or integration status of HPV, p16, and additional markers. Opportunities/barriers to cytotechnologist involvement will be addressed.