Figure 1: Mimics of a polysomic cell by FISH. When finding an abnormal cell by FISH, a CT must rule out other artifacts or entities that mimic a polysomic cell before considering the cell as abnormal. Some of these pitfalls include: 1) overlapping cells which can appear as one cell with extra signals, 2) signal splitting which is seen when signals can appear as two signals in very close proximity (but at a distance within the diameter of a signal) and 3) non-specific signals which appear as an additional signal on all four filters, but a signal appears at the exact same spot on all four filters.
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