Chapter 5.2

Hematology and Oncology Objectives and Resources

This presentation discusses the use of molecular pathology in oncology for diagnosis and treatment.  The types of cancer, the cell cycle and its checkpoints, cancer mutations, therapy based on treating specific mutations, HER2/neu, comparison of IHC vs. FISH for diagnosis, EGFR, K-ras and its mutations, EWS translocation, BRCA1 and BRCA2, RET proto-oncogene, microsatellite instability, lymphoma and leukemia, and detection of clonality. (50 slides)


  • Describe the uses of molecular pathology in the treatment and diagnosis of cancer.

Readings:  MD, Chapter 14