Chapter 5.5

Histocompatibility Objectives and Resources

This section deals with the need for the testing of organs in order to assure the best possible match between donor and recipient.  GVHD, rejection, MHC, and HLAs are defined and discussed.  HLA polymorphisms and various methods of detecting them are discussed as well. Various methods of molecular pathology and how they are used in tissue typing are also discussed.  (44 slides)



  • Discuss why matching is so important in organ transplant.
  • Discuss how the MHC controls the genetic matching of patients.
  • Describe how the molecular analysis of the MHC is done.
  • Describe the additional factors that may need to be taken into account outside of the MHC.

Readings:  MD, Chapter 15