Urine Cytology: Diagnostic Criteria, Correlation with Biopsy and an Emphasis on Ancillary Studies
Jordan P. Reynolds, MD Assistant Professor of Pathology Cleveland Clinic Cleveland, Ohio
Urothelial carcinoma continues to be a leading cause of morbidity and mortality, and urine cytology is useful for initial diagnosis and surveillance of these tumors. The Paris System of Urinary cytology has proposed standardization of reporting urine cytology specimens. In addition to morphologic criteria, there are many ancillary studies that are used in urine cytology specimens for detection of neoplastic and nonneoplastic conditions. Examples include BK FISH in polyoma virus infection, and the multicolored probe set FISH (UroVysion), Immunocyt/uCyt+ and other markers.
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